Pub. Date : 2019 May 1
PMID : 30753572
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The KPC-2 gene was cloned from the ceftazidime/avibactam-resistant isolate and evaluated for susceptibility to ceftazidime/avibactam, in an Escherichia coli background. | Ceftazidime | KPC-2 | Escherichia coli |
| 2 | The KPC-2 gene was cloned from the ceftazidime/avibactam-resistant isolate and evaluated for susceptibility to ceftazidime/avibactam, in an Escherichia coli background. | Ceftazidime | KPC-2 | Escherichia coli |
| 3 | RESULTS: A single L169P mutation was identified in the KPC-2 gene between the ceftazidime/avibactam-resistant and -susceptible isolates. | Ceftazidime | KPC-2 | Escherichia coli |
| 4 | The novel KPC-2 allele, designated KPC-35, was shown to confer reduced susceptibility to ceftazidime/avibactam and increased susceptibility to carbapenems, as compared with KPC-2. | Ceftazidime | KPC-2 | Escherichia coli |
| 5 | CONCLUSIONS: A novel L169P mutation was identified in KPC-2 and was shown through cloning experiments to confer reduced susceptibility to ceftazidime/avibactam. | Ceftazidime | KPC-2 | Escherichia coli |