Title : Novel benzoyl thioureido benzene sulfonamides as highly potent and selective inhibitors of carbonic anhydrase IX: optimization and bioactive studies.

Pub. Date : 2018 Dec 1

PMID : 30746068






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, a series of sulfonamide derivatives were designed and synthesized as potential CA IX inhibitors from a lead compound (benzoyl thioureido benzene sulfonamide) discovered by virtual screening. Sulfonamides carbonic anhydrase 9 Homo sapiens
2 The structure-activity relationship and CA IX selectivity of the new sulfonamide derivatives were also analyzed by molecular docking. Sulfonamides carbonic anhydrase 9 Homo sapiens