Title : Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage.

Pub. Date : 2019 Apr

PMID : 30735839






1 Functional Relationships(s)
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1 Furthermore, we demonstrate that SNG induces ROS-depended extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation, and prostate apoptosis response-4 (Par-4) cleavage, leading to the induction of apoptosis in human prostate cancer cells. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens