Title : High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway.

Pub. Date : 2019 Apr

PMID : 30734183






3 Functional Relationships(s)
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1 High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway. Paraquat nuclear factor, erythroid derived 2, like 2 Mus musculus
2 In vivo experiments also showed that high-dose PQ promotes inflammatory cytokines secretion, lung fibrosis and cell apoptosis, inhibits cell proliferation in mice models by regulating Keap1/p65/Nrf2 signal pathway. Paraquat nuclear factor, erythroid derived 2, like 2 Mus musculus
3 Therefore, we concluded that high-dose PQ (500 muM) inhibits 16HBE cell proliferation and autophagy, promotes cell death and mice lung fibrosis by regulating Keap1/p65/Nrf2 signal pathway. Paraquat nuclear factor, erythroid derived 2, like 2 Mus musculus