Title : High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway.

Pub. Date : 2019 Apr

PMID : 30734183






3 Functional Relationships(s)
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1 Of note, low-dose PQ (50 muM) induces cell autophagy, increases Nrf2 as well as p65 levels and has little impacts on Keap1, while high-dose PQ (500 muM) inhibits autophagy, upregulates Keap1 as well as downregulates p65 and Nrf2. Paraquat NFE2 like bZIP transcription factor 2 Homo sapiens
2 Of note, low-dose PQ (50 muM) induces cell autophagy, increases Nrf2 as well as p65 levels and has little impacts on Keap1, while high-dose PQ (500 muM) inhibits autophagy, upregulates Keap1 as well as downregulates p65 and Nrf2. Paraquat NFE2 like bZIP transcription factor 2 Homo sapiens
3 Besides, the protective effects of overexpressed p65 on high-dose PQ (500 muM) treated 16HBE cells are abrogated by synergistically knocking down Nrf2. Paraquat NFE2 like bZIP transcription factor 2 Homo sapiens