Pub. Date : 2019 Feb 7
PMID : 30733557
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Crystallographic analysis reveals that this specificity is achieved through direct binding of MEDI-579 Fab to the reactive centre loop (RCL) of PAI-1 and at the same exosite used by both tissue and urokinase plasminogen activators (tPA and uPA). | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 2 | We propose that MEDI-579 acts by directly competing with proteases for RCL binding and as such is able to modulate the interaction of PAI-1 with tPA and uPA in a way not previously described for a human PAI-1 inhibitor. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 3 | We propose that MEDI-579 acts by directly competing with proteases for RCL binding and as such is able to modulate the interaction of PAI-1 with tPA and uPA in a way not previously described for a human PAI-1 inhibitor. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |