Title : Structure-based drug design, synthesis, In vitro, and In vivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-α inhibition.

Pub. Date : 2019 Mar 15

PMID : 30731397






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1 Structure-based drug design coupled with ring opening strategy of the steroids skeleton revealed the potential of indole-based analogs to be synthesized targeting the ligand binding domain of estrogen receptor-alpha. Steroids estrogen receptor 1 Homo sapiens