Title : Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

Pub. Date : 2019 Feb 6

PMID : 30728290






1 Functional Relationships(s)
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1 Many chemotherapeutics (including anthracyclines, such as doxorubicin) induce the proapoptotic transcription factor p53 in the tumor and nonspecifically in the heart, promoting heart failure. Doxorubicin tumor protein p53 Homo sapiens