Pub. Date : 2019 Apr
PMID : 30724633
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silica nanoparticles as an enhancer in the IL-1beta-induced inflammation cycle of A549 cells. | Silicon Dioxide | interleukin 1 alpha | Homo sapiens |
| 2 | However, whether nano-SiO2 can increase the IL-1beta-induced inflammatory expression in A549 cells has not been tested. | Silicon Dioxide | interleukin 1 alpha | Homo sapiens |
| 3 | The synergistic effect of nano-SiO2 and IL-1beta was observed on the new production of IL-1beta and IL-6 in A549 cells. | Silicon Dioxide | interleukin 1 alpha | Homo sapiens |
| 4 | The Western blot results showed that nano-SiO2 can increase the expression of IL-1beta and IL-6 by promoting the phosphorylation of ERK1/2 and elevating the phosphorylation of I-kappaB by IL-1beta. | Silicon Dioxide | interleukin 1 alpha | Homo sapiens |
| 5 | The Western blot results showed that nano-SiO2 can increase the expression of IL-1beta and IL-6 by promoting the phosphorylation of ERK1/2 and elevating the phosphorylation of I-kappaB by IL-1beta. | Silicon Dioxide | interleukin 1 alpha | Homo sapiens |
| 6 | IL-1beta and IL-6 were induced by nano-SiO2, and the IL-1beta treatment with 20 muM of I-kappaBalpha phosphorylation inhibitor (PD98059) and 20 muM of ERK1/2 inhibitor (BAY11-7082) for 1 h was significantly lower than that of the control group in A549 cells. | Silicon Dioxide | interleukin 1 alpha | Homo sapiens |
| 7 | Discussion and conclusion: These results indicated that nano-SiO2 had a toxic effect on A549 cells, and this effect could increase IL-1beta on the A549 cell-induced inflammatory response. | Silicon Dioxide | interleukin 1 alpha | Homo sapiens |