Title : Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.

Pub. Date : 2019 May

PMID : 30724469






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In pancreatic cancer cells, SRPK2 downregulation or overexpression led to modulation of Numb and wild-type p53 protein expression in response to oxaliplatin treatment. Oxaliplatin tumor protein p53 Homo sapiens
2 Conversely, SRPK2 silencing decreased cell invasion and migration and increased chemosensitivity; these effects were reversed by silencing p53 in oxaliplatin-treated pancreatic cancer cells. Oxaliplatin tumor protein p53 Homo sapiens