Title : The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response.

Pub. Date : 2019 May 7

PMID : 30722038






1 Functional Relationships(s)
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1 Cancer-associated arginine mutations in the WD40 domain (R465H, R479Q and R505C) abolish both FBXW7 interaction with PAR and recruitment to DNA damage sites, causing inhibition of XRCC4 polyubiquitination and NHEJ. Arginine X-ray repair cross complementing 4 Homo sapiens