Title : Orally Delivered Antisense Oligodeoxyribonucleotides of TNF-α via Polysaccharide-Based Nanocomposites Targeting Intestinal Inflammation.

Pub. Date : 2019 Mar

PMID : 30714345






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1 Herein, a promising strategy for effective delivery of phosphorothioated antisense oligodeoxyribonucleotide of TNF-alpha (PS-ATNF-alpha), targeting the intestinal inflammation based on the interaction of the single chain of triple helical beta-glucan (s-LNT) with poly-deoxyadenylic acid [poly(dA)], and the colon-specific degradation of chitosan-alginate (CA) hydrogel, is reported. Alginates tumor necrosis factor Homo sapiens