Title : Cyclic Adenosine Monophosphate Promotes Odonto/Osteogenic Differentiation of Stem Cells from the Apical Papilla via Suppression of Transforming Growth Factor Beta 1 Signaling.

Pub. Date : 2019 Feb

PMID : 30711170






4 Functional Relationships(s)
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1 METHODS: SCAPs were stimulated with an activator of cAMP (forskolin) in the presence of either TGF-beta1 or a TGF-beta1 inhibitor. Colforsin transforming growth factor beta 1 Homo sapiens
2 METHODS: SCAPs were stimulated with an activator of cAMP (forskolin) in the presence of either TGF-beta1 or a TGF-beta1 inhibitor. Colforsin transforming growth factor beta 1 Homo sapiens
3 Moreover, the TGF-beta1 inhibitor synergized the effect of forskolin on the expression of type I collagen and runt-related transcription factor 2. Colforsin transforming growth factor beta 1 Homo sapiens
4 The results of Western blotting revealed that forskolin attenuated the unregulated expression of the phosphorylation of Smad3 and ERK induced by TGF-beta1, and a cAMP inhibitor (H89) antagonized this effect. Colforsin transforming growth factor beta 1 Homo sapiens