Title : Cyclic Adenosine Monophosphate Promotes Odonto/Osteogenic Differentiation of Stem Cells from the Apical Papilla via Suppression of Transforming Growth Factor Beta 1 Signaling.

Pub. Date : 2019 Feb

PMID : 30711170






2 Functional Relationships(s)
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1 The effect of cAMP on the phosphorylation of Smad2/Smad3 and extracellular-regulated kinase (ERK)/P38 induced by TGF-beta1 was analyzed by Western blotting. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens
2 CONCLUSIONS: This study showed that cAMP signaling exerts its up-regulating effects on the odonto/osteogenic differentiation of SCAPs by interfering with TGF-beta1 signaling via inhibiting Smad3 and ERK phosphorylation. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens