Title : Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.

Pub. Date : 2019 Aug

PMID : 30707953






3 Functional Relationships(s)
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1 Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. Morphine cAMP responsive element binding protein 1 Rattus norvegicus
2 Our results showed that neuropathic pain increased the pCREB/CREB ratio in the amygdala, and this ratio was decreased after morphine-induced anti-allodynia. Morphine cAMP responsive element binding protein 1 Rattus norvegicus
3 The potentiative effect of the coadministration of D-AP5/L-NAME on an ineffective dose of morphine also decreased the amygdala pCREB/CREB levels. Morphine cAMP responsive element binding protein 1 Rattus norvegicus