Title : Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice.

Pub. Date : 2019 Feb 15

PMID : 30699879






1 Functional Relationships(s)
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1 Moreover, simvastatin markedly prevented and ameliorated LPS and CMS-induced neuroinflammation, as shown by the suppressed activation of microglia in hippocampus and decreased hippocampal pro-inflammatory cytokines expressions including IL-1beta, TNF-alpha, IL-6, which might be mediated via the inhibition of NF-kappaB pathway, as shown by the decreased nuclear NF-kappaB p65 expression. Simvastatin interleukin 6 Mus musculus