Pub. Date : 2019 Apr 23
PMID : 30698745
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation. | Adenosine Triphosphate | RAD50 double strand break repair protein | Homo sapiens |
| 2 | However, in vitro Tel1 activation by MRX requires ATP binding to Rad50, suggesting a role also for the MR subcomplex in Tel1 activation. | Adenosine Triphosphate | RAD50 double strand break repair protein | Homo sapiens |
| 3 | By contrast, MRA78T undertakes complex opening even if Rad50 is bound to ATP, indicating that defective Tel1 activation caused by MRA78T results from destabilization of the ATP-bound conformational state. | Adenosine Triphosphate | RAD50 double strand break repair protein | Homo sapiens |
| 4 | By contrast, MRA78T undertakes complex opening even if Rad50 is bound to ATP, indicating that defective Tel1 activation caused by MRA78T results from destabilization of the ATP-bound conformational state. | Adenosine Triphosphate | RAD50 double strand break repair protein | Homo sapiens |