Title : [Protective effect of curcumin on dopamine neurons in Parkinson's disease and its mechanism].

Pub. Date : 2018 May 25

PMID : 30693689






2 Functional Relationships(s)
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1 When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05). 3-methyladenine microtubule associated protein 1 light chain 3 alpha Homo sapiens
2 When curcumin and 3-MA were given concurrently, the number of surviving dopamine neurons, protein expression of TFEB, LAMP2A and LC3-II increased (P<0.05 or P<0.01), and both protein expression and mRNA expression of alpha-Syn decreased (P<0.05 or P<0.01) compared with MPTP model group; but the number of surviving dopamine neurons and protein expression of LAMP2A and LC3-II decreased compared with curcumin group (all P<0.05). 3-methyladenine microtubule associated protein 1 light chain 3 alpha Homo sapiens