Title : ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation.

Pub. Date : 2019 Aug

PMID : 30693443






2 Functional Relationships(s)
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1 Interestingly, postmitotic cochlear cells exposed to H2O2 displayed key hallmarks of senescent cells, including dramatically increased levels of p21, p38, and p-p38 expression, concomitant with decreased p19 and BubR1 expression and positive senescence-associated beta-galactosidase labeling. Hydrogen Peroxide mitogen-activated protein kinase 14 Mus musculus
2 Interestingly, postmitotic cochlear cells exposed to H2O2 displayed key hallmarks of senescent cells, including dramatically increased levels of p21, p38, and p-p38 expression, concomitant with decreased p19 and BubR1 expression and positive senescence-associated beta-galactosidase labeling. Hydrogen Peroxide mitogen-activated protein kinase 14 Mus musculus