Title : The PERK Branch of the Unfolded Protein Response Promotes DLL4 Expression by Activating an Alternative Translation Mechanism.

Pub. Date : 2019 Jan 25

PMID : 30691003






1 Functional Relationships(s)
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1 In this study, we showed that the DLL4 5"-UTR harbors an Internal Ribosomal Entry Site (IRES) that, in contrast to cap-dependent translation, was efficiently utilized in cells subjected to several stresses including hypoxia and endoplasmic reticulum stress (ER stress). cap delta like canonical Notch ligand 4 Homo sapiens