Pub. Date : 2019 Jul
PMID : 30690033
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Itraconazole Induces Regression of Infantile Hemangioma via Downregulation of the Platelet-Derived Growth Factor-D/PI3K/Akt/mTOR Pathway. | Itraconazole | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Importantly, itraconazole significantly reduced platelet-derived growth factor-D level, resulting in suppression of platelet-derived growth factor-beta activation and inhibition of its downstream effectors, such as PI3K, Akt, 4E-BP1, and p70S6K, which are important for cellular growth and survival of infantile hemangioma. | Itraconazole | thymoma viral proto-oncogene 1 | Mus musculus |