Title : Relationships Between Neurofibromatosis-2, Progesterone Receptor Expression, the Use of Exogenous Progesterone, and Risk of Orbitocranial Meningioma in Females.

Pub. Date : 2018

PMID : 30687635






3 Functional Relationships(s)
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1 This study was aimed to examine expression of Progesterone receptor (PR) and Neurofibromatosis-2 (NF2) and assess their relationships to history of exogenous progesterone use and risk of meningioma. Progesterone NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens
2 Conclusion: In this study we showed that the longer the exposure to exogenous progesterone, the lower the expression of PR and NF2 mRNA in the serum. Progesterone NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens
3 Low expression of PR and NF2 were associated with higher risk of meningioma, suggesting that low PR expression and inactivation of NF2 might play a key role in progesterone-associated meningioma tumorigenesis and may be potential clinical marker for females at higher risk of meningioma. Progesterone NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens