Title : Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53.

Pub. Date : 2019 Jan 25

PMID : 30683842






1 Functional Relationships(s)
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1 CRBN depletion enhances the interaction between p53 and Bcl-2/Bcl-XL, reduces mitochondrial membrane potential, increases the cleavage of caspase-3 and poly(ADP-ribose) polymerase 1, and thus promotes DNA damage-induced apoptosis in cell lines and primary cells upon etoposide treatment. Etoposide transformation related protein 53, pseudogene Mus musculus