Title : Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents.

Pub. Date : 2019 Mar 1

PMID : 30683552






1 Functional Relationships(s)
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1 Some compounds exhibited potent anti-HCV activities, such as 4e and 8a-8c with similar EC50 values (0.20-0.22 muM) comparative to that of sofosbuvir (EC50 = 0.18 muM) in a genotype 1b based replicon Huh-7 cell line. Sofosbuvir latexin Homo sapiens