Title : Oroxylin A, a methylated metabolite of baicalein, exhibits a stronger inhibitory effect than baicalein on the CYP1B1-mediated carcinogenic estradiol metabolite formation.

Pub. Date : 2019 Apr

PMID : 30680817






2 Functional Relationships(s)
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1 Human cytochrome P450 1B1 (CYP1B1)-mediated formation of 4-hydroxyestradiol (4-OHE2) from 17beta-estradiol plays an important role in the progression of human breast cancer, while the biotransformation of 17beta-estradiol to 2-hydroxyestradiol mediated by cytochrome P450 1A1 (CYP1A1) is considered as a less harmful pathway. 4-hydroxyestradiol cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 Human cytochrome P450 1B1 (CYP1B1)-mediated formation of 4-hydroxyestradiol (4-OHE2) from 17beta-estradiol plays an important role in the progression of human breast cancer, while the biotransformation of 17beta-estradiol to 2-hydroxyestradiol mediated by cytochrome P450 1A1 (CYP1A1) is considered as a less harmful pathway. 4-hydroxyestradiol cytochrome P450 family 1 subfamily B member 1 Homo sapiens