Pub. Date : 2019 Feb
PMID : 30679998
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Nrf2 overexpression protects against paraquat-induced A549 cell injury primarily by upregulating P-glycoprotein and reducing intracellular paraquat accumulation. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | A previous study has demonstrated that the upregulation of nuclear factor erythroid-2 related factor 2 (Nrf2) prevents PQ toxicity in cell line and murine models. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | A previous study has demonstrated that the upregulation of nuclear factor erythroid-2 related factor 2 (Nrf2) prevents PQ toxicity in cell line and murine models. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 5 | As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 6 | As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 7 | As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 8 | As Nrf2 target genes include a group of membrane transporters, the current study assessed the protective mechanism exerted by Nrf2 against PQ toxicity and intracellular PQ accumulation via its effects on P-glycoprotein (P-gp), a downstream transporter of Nrf2. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 9 | The results revealed that overexpressed Nrf2 significantly increased P-gp protein levels, decreased the intracellular accumulation of PQ and attenuated PQ-induced toxicity. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 10 | The results revealed that overexpressed Nrf2 significantly increased P-gp protein levels, decreased the intracellular accumulation of PQ and attenuated PQ-induced toxicity. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 11 | However, the protective effects of Nrf2 overexpression on PQ-challenged A549 cells were abrogated following cyclosporine A treatment, a competitive inhibitor of P-gp, which also increased intracellular PQ levels. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 12 | However, the protective effects of Nrf2 overexpression on PQ-challenged A549 cells were abrogated following cyclosporine A treatment, a competitive inhibitor of P-gp, which also increased intracellular PQ levels. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 13 | These data indicated that Nrf2 gene overexpression prevented PQ toxicity in A549 cells, potentially via the upregulation of P-gp activity and the inhibition of intracellular PQ accumulation. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 14 | These data indicated that Nrf2 gene overexpression prevented PQ toxicity in A549 cells, potentially via the upregulation of P-gp activity and the inhibition of intracellular PQ accumulation. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 15 | Thus, Nrf2 and P-gp may serve as potential therapeutic targets for the treatment of PQ-induced injury. | Paraquat | nuclear factor, erythroid derived 2, like 2 | Mus musculus |