Title : Molecular Mechanism of Cancer Susceptibility Associated with Fok1 Single Nucleotide Polymorphism of VDR in Relation to Breast Cancer

Pub. Date : 2019 Jan 25

PMID : 30678432






2 Functional Relationships(s)
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1 In silico analysis indicatedthat SNPs may lead to a loss in affinity of VDR to calcitriol, and may also cause the impairment of normal interactionof liganded VDR with its heterodimeric partner, the retinoid X receptor (RXR), at protein level, thereby affecting targetgene transcription. Calcitriol vitamin D receptor Homo sapiens
2 In silico analysis indicatedthat SNPs may lead to a loss in affinity of VDR to calcitriol, and may also cause the impairment of normal interactionof liganded VDR with its heterodimeric partner, the retinoid X receptor (RXR), at protein level, thereby affecting targetgene transcription. Calcitriol vitamin D receptor Homo sapiens