Title : PPARĪ± and PPARĪ³ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression.

Pub. Date : 2019 Jan 15

PMID : 30674874






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1 This study provided the first demonstration that accumulation of amino acids, nucleosides, lactate, monoacylglycerols, total FFAs, and TGs in oleate-treated macrophages is effectively attenuated or even abolished by resveratrol, and that the activation of PPARalpha and PPARgamma attenuates oleate-induced total FFA and TG accumulation via suppression of Fatp1 expression in macrophages. Oleic Acid peroxisome proliferator activated receptor alpha Homo sapiens