Title : The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.

Pub. Date : 2019

PMID : 30657794






2 Functional Relationships(s)
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1 The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome. 3-Hydroxybutyric Acid NLR family, pyrin domain containing 3 Mus musculus
2 In fact, the elevated levels of retinal NLRP3 inflammasome activation markers (NLRP3, ASC, caspase-1) and of the relative proinflammatory cytokines (IL-1beta, IL-18) were significantly reduced by 50 mg/kg and 100 mg/kg beta-hydroxybutyrate treatment. 3-Hydroxybutyric Acid NLR family, pyrin domain containing 3 Mus musculus