Title : Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation.

Pub. Date : 2019 Apr

PMID : 30653357






1 Functional Relationships(s)
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1 Activation of the NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome plays a key role in host immune response, which is the first line of defense against cellular stresses and pathogen infections. Leucine NLR family pyrin domain containing 3 Homo sapiens