Title : The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial.

Pub. Date : 2019 Mar

PMID : 30652208






1 Functional Relationships(s)
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1 Since metronomic cyclophosphamide (CTX) was shown to selectively deplete Tregs, a phase 1 clinical trial was conducted to comprehensively investigate the immune-modulating effects of several dosages and schedules of CTX in combination with the standard dose of everolimus, with the explicit aim to achieve selective Treg depletion. Cyclophosphamide cytochrome P450 family 27 subfamily A member 1 Homo sapiens