Title : Effectiveness and Safety of Clopidogrel Co-administered With Statins and Proton Pump Inhibitors: A Korean National Health Insurance Database Study.

Pub. Date : 2019 Jul

PMID : 30648733






2 Functional Relationships(s)
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1 Simultaneous competition for cytochrome P450 (CYP) 2C19 and CYP3A4 might diminish clopidogrel"s antiplatelet effect by impacting its metabolic activation. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 This pharmacoepidemiologic study investigated whether proton pump inhibitors (PPIs) and CYP3A4-metabolized statins individually and jointly increase thrombotic events by attenuating clopidogrel"s effectiveness. Clopidogrel cytochrome P450 family 3 subfamily A member 4 Homo sapiens