Title : Phorbol ester-induced angiogenesis of endothelial progenitor cells: The role of NADPH oxidase-mediated, redox-related matrix metalloproteinase pathways.

Pub. Date : 2019

PMID : 30645596






3 Functional Relationships(s)
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1 Phorbol-12-myristate-13-acetate (PMA), a PKCalpha activator, significantly increased the activity and expression of matrix metalloproteinases (MMP) -2 and -9 in human (late outgrowth) EPCs in vitro. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
2 Phorbol-12-myristate-13-acetate (PMA), a PKCalpha activator, significantly increased the activity and expression of matrix metalloproteinases (MMP) -2 and -9 in human (late outgrowth) EPCs in vitro. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens
3 PMA could activate PKCalpha and promote the angiogenesis capacity of human EPCs via NADPH oxidase-mediated, redox-related, MMP-2 and MMP-9 pathways. Tetradecanoylphorbol Acetate protein kinase C alpha Homo sapiens