Title : Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity.

Pub. Date : 2019 Jan 15

PMID : 30644819






1 Functional Relationships(s)
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1 Here, we show that mutation of six residues in TRPV3 corresponding to the vanilloid site in TRPV1 is sufficient to engineer RTx binding. Capsaicin transient receptor potential cation channel subfamily V member 3 Homo sapiens