Pub. Date : 2019 Feb 20
PMID : 30643918
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1beta from human hepatic cells. | arsenite | interleukin 1 alpha | Homo sapiens |
2 | In L-02 cells, the over-expression of miR-379-5p blocked the arsenite-induced increases of GSDMD levels and the release of IL-1beta, effects that were reversed by up-regulation of GSDMD. | arsenite | interleukin 1 alpha | Homo sapiens |
3 | Activation of LX-2 cells by media from arsenite-treated L-02 cells was inhibited by IL-1beta neutralizing antibody. | arsenite | interleukin 1 alpha | Homo sapiens |
4 | The media from arsenite-treated L-02 cells transfected with an miR-379-5p mimic inhibited the activation of LX-2 cells, a process that was reversed by up-regulation of GSDMD and by co-treatment with human recombinant IL-1beta. | arsenite | interleukin 1 alpha | Homo sapiens |