Title : Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1β from human hepatic cells.

Pub. Date : 2019 Feb 20

PMID : 30643918






4 Functional Relationships(s)
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1 Regulation of gasdermin D by miR-379-5p is involved in arsenite-induced activation of hepatic stellate cells and in fibrosis via secretion of IL-1beta from human hepatic cells. arsenite interleukin 1 alpha Homo sapiens
2 In L-02 cells, the over-expression of miR-379-5p blocked the arsenite-induced increases of GSDMD levels and the release of IL-1beta, effects that were reversed by up-regulation of GSDMD. arsenite interleukin 1 alpha Homo sapiens
3 Activation of LX-2 cells by media from arsenite-treated L-02 cells was inhibited by IL-1beta neutralizing antibody. arsenite interleukin 1 alpha Homo sapiens
4 The media from arsenite-treated L-02 cells transfected with an miR-379-5p mimic inhibited the activation of LX-2 cells, a process that was reversed by up-regulation of GSDMD and by co-treatment with human recombinant IL-1beta. arsenite interleukin 1 alpha Homo sapiens