Pub. Date : 2018
PMID : 30622965
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we aimed to evaluate the role of Wnt 10a/beta-catenin signaling in DEX-induced alleviation of DNP in rats. | dnp | catenin beta 1 | Rattus norvegicus |
| 2 | Rats with STZ-induced DNP had a decreased pain threshold, activated astrocytes, increased expression of Wnt 10a and beta-catenin, and increased levels of proinflammatory cytokines compared to the control group, and these effects were ameliorated by treatment with DEX. | dnp | catenin beta 1 | Rattus norvegicus |
| 3 | In conclusion, DEX alleviated DNP in rats by inhibiting inflammation and astrocyte activation, which may be attributed to downregulation of the Wnt 10a/beta-catenin signaling pathway. | dnp | catenin beta 1 | Rattus norvegicus |