Title : Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors.

Pub. Date : 2019 Apr

PMID : 30622011






1 Functional Relationships(s)
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Protein Name
Organism
1 These chalcone derivatives had Ki values in the range of 19.58-78.73 nM for hCA I, 12.23-41.70 nM for hCA II, 1.09-6.84 nM for AChE, 8.30-32.30 nM for BChE and 0.93 +- 0.20-18.53 +- 5.06 nM against alpha-glycosidase. Chalcone acetylcholinesterase (Cartwright blood group) Homo sapiens