Title : Pre- and postsynaptic actions of GABA on the release of hypothalamic gonadotropin-releasing hormone (GnRH).

Pub. Date : 1988 Oct

PMID : 3061570






12 Functional Relationships(s)
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1 Pre- and postsynaptic actions of GABA on the release of hypothalamic gonadotropin-releasing hormone (GnRH). gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
2 The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
3 The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
4 The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
5 The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
6 Perifusion with GABA (10(-8)-10(-4) M) caused a dose-dependent increase in GnRH release. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
7 The specific GABAA antagonist SR95103 (10(-6) M) caused a reduction of basal GnRH release and completely blocked that induced by GABA (10(-4) M). gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
8 The GABA-induced stimulation of GnRH release was also prevented when the hypothalamic slices were treated with a corticotropin releasing hormone (CRH) antagonist (alpha-helical CRF9-41, 10(-6) M) or the opioid antagonist naloxone (10(-6) M). gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
9 These results lead us to conclude that GABA exerts two opposing effects upon GnRH neuronal activity: it acts in an inhibitory fashion at GnRH nerve terminals and in a stimulatory fashion at GnRH perikarya; the latter might occur through GABAergic inhibition of CRH release and, therefore, of opioid peptide release. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
10 These results lead us to conclude that GABA exerts two opposing effects upon GnRH neuronal activity: it acts in an inhibitory fashion at GnRH nerve terminals and in a stimulatory fashion at GnRH perikarya; the latter might occur through GABAergic inhibition of CRH release and, therefore, of opioid peptide release. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
11 These results lead us to conclude that GABA exerts two opposing effects upon GnRH neuronal activity: it acts in an inhibitory fashion at GnRH nerve terminals and in a stimulatory fashion at GnRH perikarya; the latter might occur through GABAergic inhibition of CRH release and, therefore, of opioid peptide release. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus
12 Lastly, all the effects of GABA upon GnRH release appear to be mediated through GABAA receptors. gamma-Aminobutyric Acid gonadotropin releasing hormone 1 Rattus norvegicus