Pub. Date : 1988 Oct
PMID : 3061570
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pre- and postsynaptic actions of GABA on the release of hypothalamic gonadotropin-releasing hormone (GnRH). | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 2 | The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 3 | The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 4 | The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 5 | The role of gamma-aminobutyric acid (GABA) in the regulation of gonadotropin hormone-releasing hormone (GnRH) release was studied using rat hypothalamic slices in vitro. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 6 | Perifusion with GABA (10(-8)-10(-4) M) caused a dose-dependent increase in GnRH release. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 7 | The specific GABAA antagonist SR95103 (10(-6) M) caused a reduction of basal GnRH release and completely blocked that induced by GABA (10(-4) M). | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 8 | The GABA-induced stimulation of GnRH release was also prevented when the hypothalamic slices were treated with a corticotropin releasing hormone (CRH) antagonist (alpha-helical CRF9-41, 10(-6) M) or the opioid antagonist naloxone (10(-6) M). | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 9 | These results lead us to conclude that GABA exerts two opposing effects upon GnRH neuronal activity: it acts in an inhibitory fashion at GnRH nerve terminals and in a stimulatory fashion at GnRH perikarya; the latter might occur through GABAergic inhibition of CRH release and, therefore, of opioid peptide release. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 10 | These results lead us to conclude that GABA exerts two opposing effects upon GnRH neuronal activity: it acts in an inhibitory fashion at GnRH nerve terminals and in a stimulatory fashion at GnRH perikarya; the latter might occur through GABAergic inhibition of CRH release and, therefore, of opioid peptide release. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 11 | These results lead us to conclude that GABA exerts two opposing effects upon GnRH neuronal activity: it acts in an inhibitory fashion at GnRH nerve terminals and in a stimulatory fashion at GnRH perikarya; the latter might occur through GABAergic inhibition of CRH release and, therefore, of opioid peptide release. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |
| 12 | Lastly, all the effects of GABA upon GnRH release appear to be mediated through GABAA receptors. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Rattus norvegicus |