Pub. Date : 2019 Jun
PMID : 30614034
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Signaling Crosstalk of FHIT, p53, and p38 in etoposide-induced apoptosis in MCF-7 cells. | Etoposide | tumor protein p53 | Homo sapiens |
| 2 | The time course study showed that the expression of FHIT, p53, and p38MAPK started after 1 hour following etoposide treatment. | Etoposide | tumor protein p53 | Homo sapiens |
| 3 | Thus, activation of p38 upon etoposide treatment leads to increase in FHIT and p53 expression. | Etoposide | tumor protein p53 | Homo sapiens |
| 4 | In p53 knockdown MCF-7, the FHIT induction was hampered but p38 activation was induced in lower doses of etoposide. | Etoposide | tumor protein p53 | Homo sapiens |
| 5 | Our data demonstrated that the exposure of MCF-7 cells to etoposide increases apoptosis through a mechanism involving the activation of the p38-FHIT-p53 pathway. | Etoposide | tumor protein p53 | Homo sapiens |