Pub. Date : 2018 Nov
PMID : 30607725
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A method for determination of hydroxylase activity of cytochrome P450 3A4 (CYP3A4) towards its substrate hydrocortisone using fluorescent analysis of the product was developed. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | A method for determination of hydroxylase activity of cytochrome P450 3A4 (CYP3A4) towards its substrate hydrocortisone using fluorescent analysis of the product was developed. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | 6beta-hydroxycortisol, formed during CYP3A4-dependent electrocatalysis, has a characteristic fluorescent peak at lambda = 427 +- 2 nm after treating with the sulfuric acid : ethanol (3 : 1) mixture and excitation at lambda = 365 nm, which is different from the substrate (hydrocortisone) fluorescence (lambda = 525 +- 2 nm). | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The developed analytical approach was used to determine the kinetic parameters of CYP3A4-dependent hydrocortisone hydroxylation. | Hydrocortisone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |