Title : 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.

Pub. Date : 2019 Jun

PMID : 30607691






1 Functional Relationships(s)
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1 RESULTS: The results indicated that 4-PBA attenuated the following: (1) pancreas and intestinal pathological injuries, (2) serum TNF-alpha, IL-1beta, and IL-6, (3) serum DAO level, serum endotoxin level, (4) the apoptosis of IECs, (5) ER stress markers (caspase-12, CHOP, GRP78, PERK, IRE1alpha, ATF6) and caspase-3 expression in intestinal. 4-phenylbutyric acid caspase 3 Rattus norvegicus