Pub. Date : 2019 Apr
PMID : 30607468
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In crude membranes, the activity of AC9 in the presence of GDP-beta-S was enhanced by miconazole with an EC50 of ~ 8 muM, while AC1 and AC2 were inhibited with an IC50 of ~ 20 muM. | Miconazole | adenylate cyclase 9 | Homo sapiens |
| 2 | Substrate saturation analysis indicated that miconazole increased the Vmax of AC9 by 3-fold while having no effect on the Km. | Miconazole | adenylate cyclase 9 | Homo sapiens |
| 3 | In intact cells, the effect of miconazole on cAMP production through AC9 was additive with that of isoproterenol. | Miconazole | adenylate cyclase 9 | Homo sapiens |
| 4 | In sum, activation of AC9 by miconazole is through a mechanism distinct from that of forskolin, activated G proteins, or the COOH-terminal mediated autoinhibition. | Miconazole | adenylate cyclase 9 | Homo sapiens |