Pub. Date : 2019 Mar
PMID : 30605787
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition potency of the sulfonamides were evaluated against human CA isoenzymes (hCA IandhCA II) and acetylcholinesterase (AChE) enzyme and also their cytotoxicities were investigated towards oral squamous cancer cell carcinoma (OSCC) cell lines (Ca9-22, HSC-2, HSC-3, and HSC-4) and non-tumor cells (HGF, HPLF, and HPC). | Sulfonamides | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | AChE enzyme was strongly inhibited by the sulfonamide derivatives with Ki values in the range of 37.7 +- 14.4-89.2 +- 30.2 nM The CC50 values of the compounds were found between 15 and 200 microM towards OSCC malign cell lines. | Sulfonamides | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | All sulfonamide derivatives studied here can be considered as good candidates to develop novel CAs or AChE inhibitor candidates based on the enzyme inhibition potencies with their low cytotoxicity and tumor selectivity. | Sulfonamides | acetylcholinesterase (Cartwright blood group) | Homo sapiens |