Title : The investigation of allosteric regulation mechanism of analgesic effect using SD rat taste bud tissue biosensor.

Pub. Date : 2019 Feb 1

PMID : 30602263






3 Functional Relationships(s)
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1 Capsaicin was used as a TRPV1 noxious ion channel activator to investigate the antagonism kinetics of six different substances on capsaicin. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 This indicates that vanilloid activators turn on the TRPV1 ion channel to transmit only pain and other nociceptive signals, while capsaicin and its competitive ligands are capable of activating intracellular G protein/PI3K/PIP2 signaling pathways by binding to endogenous cannabinoid receptors, and then increase intracellular PIP2 levels (the increasing PIP2 can competitively replace capsaicin and other vanilloid activators), thereby closing the TRPV1 channel and exerting the analgesic effect. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
3 This indicates that vanilloid activators turn on the TRPV1 ion channel to transmit only pain and other nociceptive signals, while capsaicin and its competitive ligands are capable of activating intracellular G protein/PI3K/PIP2 signaling pathways by binding to endogenous cannabinoid receptors, and then increase intracellular PIP2 levels (the increasing PIP2 can competitively replace capsaicin and other vanilloid activators), thereby closing the TRPV1 channel and exerting the analgesic effect. Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus