Pub. Date : 2019 Feb 22
PMID : 30598505
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although alpha4 integrin is known to be a potential target of reactive oxygen species (ROS)-induced cysteine glutathionylation, the physiological significance and underlying regulatory mechanism of this event remain elusive. | Reactive Oxygen Species | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 2 | Although alpha4 integrin is known to be a potential target of reactive oxygen species (ROS)-induced cysteine glutathionylation, the physiological significance and underlying regulatory mechanism of this event remain elusive. | Reactive Oxygen Species | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 3 | Here, using in vitro and in vivo biochemical and cell biology approaches, we show that physiological ROS-induced glutathionylation of alpha4 integrin in neutrophils increases the binding of neutrophil-associated alpha4 integrin to vascular cell adhesion molecule 1 (VCAM-1) on human endothelial cells. | Reactive Oxygen Species | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 4 | Here, using in vitro and in vivo biochemical and cell biology approaches, we show that physiological ROS-induced glutathionylation of alpha4 integrin in neutrophils increases the binding of neutrophil-associated alpha4 integrin to vascular cell adhesion molecule 1 (VCAM-1) on human endothelial cells. | Reactive Oxygen Species | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 5 | Taken together, our results establish ROS-elicited glutathionylation and its modulation by Grx1 as pivotal regulatory mechanisms controlling alpha4 integrin affinity and neutrophil mobilization from the bone marrow under physiological conditions. | Reactive Oxygen Species | immunoglobulin (CD79A) binding protein 1 | Mus musculus |