Pub. Date : 2019 Jan
PMID : 30597502
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | tPA Point Mutation at Autolysis Loop Enhances Resistance to PAI-1 Inhibition and Catalytic Activity. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 2 | To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 3 | To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 4 | To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 5 | To improve the proteolytic properties of tPA to enhance thrombolytic therapy, we designed a series of mutants in tPA serine protease domain (tPA-SPD) based on the crystal structure of tPA-SPD:plasminogen activators inhibitor-1 (PAI-1) complex that we determined recently. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 6 | We found that the A146Y substitution in tPA-SPD(A146Y) enhanced resistance to PAI-1 inactivation by 30-fold compared with original tPA-SPD. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 7 | We found that the A146Y substitution in tPA-SPD(A146Y) enhanced resistance to PAI-1 inactivation by 30-fold compared with original tPA-SPD. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 8 | Together, our findings reveal novel functions of A146Y variant, which not only increases the catalytic efficiency of the enzyme, but also enhances resistance to PAI-1 inhibition, and demonstrating that tPA-SPD (A146Y) variant is a much improved agent for thrombolytic therapy. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |