Title : Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.

Pub. Date : 2019

PMID : 30594931






1 Functional Relationships(s)
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1 Affinity chromatography analysis of striatal lysates showed that Huntingtin is in a complex with Rac1, p85alpha subunit of PI 3-kinase, and the actin bundling protein alpha-actinin and interacts preferentially with the GTP bound form of Rac1. Guanosine Triphosphate huntingtin Mus musculus