Title : Development of a liver-specific Tet-off AAV8 vector for improved safety of insulin gene therapy for diabetes.

Pub. Date : 2019 Jan

PMID : 30592790






4 Functional Relationships(s)
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1 We have previously shown that a single injection of an adeno-associated virus serotype 8 (AAV8) vector carrying a modified and codon optimized human insulin gene induced hepatic production of insulin and corrected streptozotocin (STZ)-induced diabetes in mice for more than 1 year. Streptozocin insulin Homo sapiens
2 We have previously shown that a single injection of an adeno-associated virus serotype 8 (AAV8) vector carrying a modified and codon optimized human insulin gene induced hepatic production of insulin and corrected streptozotocin (STZ)-induced diabetes in mice for more than 1 year. Streptozocin insulin Homo sapiens
3 RESULTS: Using STZ-induced diabetic mice, we were able to switch off insulin secretion repeatedly with doxycycline administration, and showed full restoration of insulin secretion on withdrawing doxycycline. Streptozocin insulin Homo sapiens
4 RESULTS: Using STZ-induced diabetic mice, we were able to switch off insulin secretion repeatedly with doxycycline administration, and showed full restoration of insulin secretion on withdrawing doxycycline. Streptozocin insulin Homo sapiens