Pub. Date : 2019 Feb 5
PMID : 30591217
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long noncoding RNA MALAT1 promotes high glucose-induced human endothelial cells pyroptosis by affecting NLRP3 expression through competitively binding miR-22. | Glucose | metastasis associated lung adenocarcinoma transcript 1 | Homo sapiens |
| 2 | Then, we investigated lncRNA MALAT1 expression and found that it was upregulated in high glucose-treated EA.hy926 cells. | Glucose | metastasis associated lung adenocarcinoma transcript 1 | Homo sapiens |
| 3 | Furthermore, lncRNA MALAT1 knockdown significantly inhibited high glucose-induced pyroptosis in EA.hy926 cells, which may critically influence atherosclerosis. | Glucose | metastasis associated lung adenocarcinoma transcript 1 | Homo sapiens |
| 4 | Ultimately, miR-22 overexpression abrogated the effect of MALAT1 on high glucose-induced EA.hy926 cells pyroptosis. | Glucose | metastasis associated lung adenocarcinoma transcript 1 | Homo sapiens |
| 5 | Together, our results suggest that lncRNA MALAT1 promotes high glucose-induced pyroptosis of endothelial cells partly by affecting NLRP3 expression through competitively binding miR-22. | Glucose | metastasis associated lung adenocarcinoma transcript 1 | Homo sapiens |