Title : Intra-periaqueductal gray matter administration of orexin-A exaggerates pulpitis-induced anxiogenic responses and c-fos expression mainly through the interaction with orexin 1 and cannabinoid 1 receptors in rats.

Pub. Date : 2019 Feb

PMID : 30587409






3 Functional Relationships(s)
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1 Here, the role of vlPAG OX1Rs and their interaction with cannabinoid 1 (CB1) receptor was evaluated in anxiety-like behavior following capsaicin-induced dental pulp pain. Capsaicin cannabinoid receptor 1 Rattus norvegicus
2 Blockage of OX1R and CB1 receptors attenuated the effect of orexin-A on c-fos expression in capsaicin-treated rats. Capsaicin cannabinoid receptor 1 Rattus norvegicus
3 In conclusion, the data suggest that manipulation of OX1R and CB1 receptors in the vlPAG alters capsaicin-evoked anxiety like behaviors and c-fos induction in rats. Capsaicin cannabinoid receptor 1 Rattus norvegicus